
Human airway maintenance results from neutral competition of basal cells
and is accelerated in smokers
V. H. Teixeira, P. Nadarajan, T. Graham, M. Falzon, E. Nye, C. P. Pipinikas,
R. Poulsom, D. Lawrence, N. Wright, S. McDonald, A. Giangreco, B. D. Simons,
and S. M. Janes
in preparation
Lgr5 intestinal stem cells carrying oncogenic K-ras mutations outcompete wt
stem cells and augment crypt fission rate
A. G. Schepers, H. J. Snippert, J. H. van Es, B. D. Simons, and H.
Clevers
in preparation
JAK2 V617F alters the balance of self-renewal and differentiation in single
mouse hematopoietic stem cells
D. G Kent, J. Li, H. Tanna, B. D. Simons, and A. R. Green
Plos Biology, in press
Multipotent and unipotent progenitors contribute to prostate postnatal
development
M. Ousset, A. van Keymuelen, G. Bouvencourt, N. Sharma, Y. Achouri, B. D.
Simons, and C. Blanpain
Nature Cell Biology 14, 1131-8 (2012)
How variable clones build and invariant retina
J. He, G. Zhang, A. D. Almeida, M. Cayouette, B. D. Simons, and W. A. Harris
Neuron 75, 786-798 (2012)
Preview: Deterministic or Stochastic Choices in Retinal Neuron Specification
Distinct contribution of stem cells and progenitors to epidermal
homeostasis and repair
G. Mascre, B. Drogat, S. Dekoninck, K. K. Youseff, S. Brohee, P. Sotiropoulou,
B. D. Simons, and C. Blanpain
Nature, 489, 257-62 (2012)
Research Highlight: Stem cells: Hierarchy in the population
News and Views: Cell biology: Dormant and restless skin stem cells
A single progenitor population switches behavior to maintain repair
esophageal epithelium
D. P. Doupe, M. P. Alcolea, A. Roshan, G. Zhang, A. M. Klein, B. D. Simons, and
P. H. Jones
Science 337, 1091-1093 (2012)
Commentary: Science perspectives
Defining the mode of tumour growth by clonal analysis
G. Driessens, B. Beck, A. Caauwe, B. D. Simons and C. Blanpain
Nature 488, 527-530 (2012)
Commentaries: Nature news;
Nature, News and Views;
Science Now;
Cancer research UK;
Press reports:
ABC News;
BBC News;
Boston Globe;
Dail Mail;
eCancer;
El Pais;
Independent;
LA Times;
Medical Daily;
NPR News;
Telegraph;
The Scientist
Info: Stem cells and cancer
Drosophila midgut homeostasis involves neutral competition between
symmetrically dividing stem cells
J. de Navascues, C. Perdigoto, A. Bardin, A. Martinez-Arias, and B. D.
Simons
EMBO journal 31, 2473-85 (2012)
Commentary: Intestinal stem cells: no longer immortal but ever so clever...
Patterning as a signature of human epidermal stem cell regulation
A. M. Klein, D. P. Doupe, B. Nikolaidou-Neokosmidou, P. H. Jones and B. D. Simons
J. R. Soc. Interface 8, 1815-1824 (2011)
Stem cell self-renewal in intestinal crypt
B. D. Simons and H. Clevers
Experimental Cell
Research 317, 2719-2724 (2011)
Universal patterns of stem cell fate in cycling tissues
A. M. Klein and B. D. Simons
Development
138, 3103-3111 (2011)
Strategies of stem cell self-renewal in adult tissues
B. D. Simons and H. Clevers
Cell
145, 851-862 (2011)
Reconstruction of rat retinal progenitor cell lineages reveals a surprising
degree of stochasticity in cell fate decisions
F. L. A. F. Gomes, G. Zhang, F. Carbonell, J. A. Correa, W. A. Harris, B. D.
Simons, and M. Cayouette
Development 138, 227-235 (2011)
Intestinal crypt homeostasis results from
neutral competition between symmetrically dividing Lgr5 stem cells
H. J. Snippert, L. G. van der Flier, T. Sato, J. H. van Es, M. van den Born,
C. Kroon-Veenboer, N. Barker, A. M. Klein, J. van Rheenen, B. D. Simons, and
H. Clevers
Cell
143, 134-144 (2010).
Commentaries: Nature Reviews: Molecular Cell Biology;
Developmental Cell;
Nature News and Views
Intestinal stem cell replacement follows a pattern of neutral drift
C. Lopez-Garcia, A. M. Klein, B. D. Simons, and D. J. Winton
Science 330, 822-825 (2010)
Commentary: Development
Mouse germ line stem cells undergo rapid and stochastic turnover
A. M. Klein, T. Nakagawa, R. Ichikawa, S. Yoshida, and B. D. Simons
Cell Stem Cell 7, 214-224 (2010)
Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward
proliferation by UV B during preneoplasia
A. M. Klein, D. E. Brash, P. H. Jones, and B. D. Simons
Proceedings of the National Academy of Sciences 107, 270 (2010)
The ordered architecture of ear epidermis is maintained by progenitor cells
with random fate
D. P. Doupe, A. M. Klein, B. D. Simons, and P. H. Jones
Developmental Cell 18, 317 (2010)
Epidermal homeostasis: do committed progenitors work while stem cells
sleep?
P. H. Jones and B. D. Simons
Nature Reviews: Molecular Cell Biology 9 , 82-8 (2008)
Mechanism of murine epidermal maintenance: Cell division and the Voter
Model
A. M. Klein, D. P. Doupe, P. H. Jones, and B. D. Simons
Phys. Rev. E.
77, 031907 (2008) |
arxiv abstract
Sic transit gloria: Farewell to the epidermal transit amplifying
cell?
P. H. Jones, B. D. Simons, and F. M. Watt
Cell Stem Cell 1, 371 (2007)
Kinetics of cell division in epidermal maintenance
A. M. Klein, D. P. Doupe, P. H. Jones, and B. D. Simons
Phys. Rev. E.
76, 021910 (2007) |
arxiv abstract
A single type of progenitor cell maintains the epidermis
E. Clayton, D. P. Doupe, A. M. Klein, D. Winton, B. D. Simons, and P. H.
Jones
Nature 446, 185 (2007) |
pdf
Vesicles and onion phases in dilute surfactant solutions
B. D. Simons and M. E. Cates
J. de Physique II (Paris) 2, 1439 (1992).
Stability of dipolar fluid membranes
B. D. Simons
J. de Physique II (Paris) 2, 1141 (1992).