Note that recent papers may be available through Open Access from Apollo, the University of Cambridge manuscript repository. To find papers by the Simons lab, search on "Simons BD".



  1. A unifying theory of branching morphogenesis
    E. Hannezo*, C. L. G. J. Scheele, M. Moad, N. Drogo, R. Heer, R. V. Sampogna, J. van Rheenen* and B. D. Simons*
    Cell 171, 242-255 (2017) | doi: 10.1016/j.cell.2017.08.026
    Commentary: Scientists reveal the "beautiful" simplicity underlying branching patterns in tissue

  2. Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment
    X. Lan, D. J. Jörg, L. V. Nguyen, R. J. Vanner, D. Pellacani, L. Lee, N. I. Park, M. Kushida, H. Whetstone, A. Carles, M. Moksa, R. Head, F. J. Coutinho, H. J. Selvadurai, S. Dolma, P. Prinos, M. Bernstein, C. H. Arrowsmith, M. Gallo, M. Hirst, C. J. Eaves, B. D. Simons* and P. B. Dirks*
    Nature 549, 227-232 (2017) | doi:10.1038/nature23666
    Commentary: Stem cells - masters of their fates
    Press reports: Toronto Star | CTV News

  3. Emergence and universality in the regulation of stem cell fate
    S. Rulands and B. D. Simons
    Current Opinion in Systems Biology 5, 57-62 (2017) | doi: 10.1016/j.coisb.2017.08.001

  4. Multipotent basal stem cells, maintained in localized proximal niches, support directed long-ranging epithelial flows in the adult human prostate
    M. Moad, E. Hannezo, S. J. Buczacki, L. Wilson, A. El Sherif, D. Sims, R. Pickard, N. A. Wright, S. C. Williamson, D. M. Turnbull, R. W. Taylor, L. Greaves, C. N. Robson, B. D. Simons* and Rakesh Heer*
    Cell Reports 20, 1609–1622 (2017) | doi:10.1016/j.celrep.2017.07.061

  5. Multi-site Neurogenin3 phosphorylation controls pancreatic endocrine differentiation
    R. Azzarelli, C. Hurley, M. K. Sznurkowska, S. Rulands, L. Hardwick, I Gamper, F. Ali, L. McCracken, C. Hindley, F. McDuff, S. Nestorowa, R. Kemp, K. Jones, B. Göttgens, M. Huch, G. Evan, B. D. Simons, D. J. Winton and A. Philpott
    Developmental Cell 41, 274-286 (2017) | doi:10.1016/j.devcel.2017.04.004
    Commentary: Beta Cell Renewal versus Differentiation: Slow and Steady Wins the Race

  6. Long-term organoid cultures of human endometrium in chemically-defined medium respond to reproductive hormones
    M. Y. Turco, L. Gardner, J. Hughes, T. Cindrova-Davies, M. J. Gomez, L. Farrell, M. Hollinshead, S. G. E. Marsh, J. J. Brosens, H. O. Critchley, B. D. Simons, M. Hemberger, B.-K. Koo, A. Moffett and G. Burton
    Nature Cell Biology, published online 10 April 2017 | doi:10.1038/ncb3516
    Commentary: Miniature "womb lining" grown in lab could reveal secrets of menstrual cycle and early pregnancy

  7. Identity and dynamics of mammary stem cells during branching morphogenesis
    C. L. G. J. Scheele, E. Hannezo, A. Zomer, N. S. M. Langedijk, B. D. Simons* and J. van Rheenen*
    Nature 542, 313-317 (2017) | doi:10.1038/nature21046
    Preview: Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis

  8. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis
    M. Aragona, S. Dekoninck, S. Rulands, S. Lenglez, G. Mascré, B. D. Simons and C. Blanpain
    Nature Communications 8, 14684 (2017) | doi:10.1038/ncomms14684

  9. Extensive Proliferation of a Subset of Differentiated, Yet Plastic, Medial Vascular Smooth Muscle Cells Contribute to Neointimal Formation in Mouse Injury and Atherosclerosis Models
    J. Chappell, J. L. Harman, V. M. Narasimhan, H. Yu, K. Foote, B. D. Simons, M. R. Bennett and H. F. Jorgensen
    Circulation Research 119, 1313-1323 (2016) | doi:10.1161/CIRCRESAHA.116.309799

  10. A single dividing cell population with imbalanced fate drives oesophageal tumour growth
    J. Frede, P. Greulich, T. Nagy, B. D. Simons and P. H. Jones
    Nature Cell Biology 18, 967-78 (2016). | doi:10.1038/ncb3400

  11. Tracing cellular dynamics in tissue development, maintenance and disease
    S. Rulands and B. D. Simons
    Curr. Opin. Cell Bio. 43, 38-45 (2016) | doi: 10.1016/j.ceb.2016.07.001

  12. Defining the clonal dynamics leading to mouse skin tumour initiation
    A. Sanchez-Danes, E. Hannezo, J.-C. Larsimont, M. Liagre, K. K. Youssef, B. D. Simons* and C. Blanpain*
    Nature 536, 298-303 (2016) | doi:10.1038/nature19069
    Commentary: Where did it all go wrong?

  13. Dynamic heterogeneity as a strategy of stem cell self-renewal
    P. Greulich and B. D. Simons
    Proc Natl Acad Sci U S A 113, 7509-7514 (2016) | doi: 10.1073/pnas.1602779113

  14. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing
    E. Rognoni, C. Gomez, A. O. Pisco, E. L. Rawlins, B. D. Simons, F. M. Watt, R. R. Driskell
    Development 143, 2522-2535 (2016) | doi: 10.1242/dev.131797

  15. Quantitative lineage tracing strategies to resolve multipotency in tissue specific stem cells
    A. Wuidart, M. Ousset, S. Rulands, B. D. Simons, A. Van Keymeulen and C. Blanpain
    Genes and Development 30, 1261-1277 (2016) | doi: 10.1101/gad.280057.116

  16. 2D and 3D stem cell models of primate cortical development identify species-specific differences in progenitor behavior contributing to brain size
    T. Otani, M. C. Matchetto, F. H. Gage, B. D. Simons and F. J. Livesey
    Cell Stem Cell 18, 467-480 (2016) | doi: 10.1016/j.stem.2016.03.003
    Preview: Stem cells expand insights into human brain evolution

  17. The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue
    Y. Wan, A. D. Almeida, S. Rulands, N. Chalour, L. Muresan, Y. Wu, B. D. Simons, J. He and W. Harris
    Development 143, 1099-1107 (2016) | doi: 10.1242/dev.133314

  18. Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking
    B. D. Simons
    Proc Natl Acad Sci U S A 113, E1130-31 (2016) | doi: 10.1073/pnas.1601045113

  19. Deep sequencing as a probe of stem cell fate and preneoplasia in human epidermis
    B. D. Simons
    Proc Natl Acad Sci U S A 113, 128-133 (2016) | doi: 10.1073/pnas.1516123113

  20. Uncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesis
    S. Chabab, F. Lescroart, S. Rulands, N. Mathiah, B. D. Simons* and C. Blanpain*
    Cell Reports 14, 1-10 (2016) | doi: 10.1016/j.celrep.2015.12.013

  21. Human keratinocytes have two interconvertible modes of proliferation
    A. Roshan, K. Murai, J. Fowler, B. D. Simons, V. Nikolaidou-Neokosmidou and P. H. Jones
    Nature Cell Biology 18, 145-156 (2015) | doi: 10.1038/ncb3282

  22. Dynamics of Lgr6+ progenitor cells in the hair follicle, sebaceous gland and interfollicular epidermis
    A. Füllgrabe, S. Joost, A. Are, T. Jacob, U. Sivan, A. Haegebarth, S. Linnarsson, B. D. Simons, H. Clevers, R. Toftgård and M. Kasper
    Stem Cell Reports 5, 843-855 (2015) | doi: 10.1016/j.stemcr.2015.09.013

  23. Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
    R. R. Giraddi, M. Shehata, M. Gallardo, M. A. Blasco, B. D. Simons and J. Stingl
    Nature Communications 6, 8487 (2015) | doi: 10.1038/comms9487

  24. The independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retina
    H. Boije, S. Rulands, S. Dudczig, B. D. Simons and W. A. Harris
    Developmental Cell 34, 532-543 (2015) | doi: 10.1016/j.devcel.2015.08.011

  25. Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT dependent manner
    G. Kolahgar, S. J. E. Suijkerbuijk, E. Poirier, S. Mansour, B. D. Simons and E. Piddini
    Developmental Cell 34, 297-309 (2015) | doi: 10.1016/j.devcel.2015.06.010

  26. Clonal dynamics reveal two distinct populations of basal cells in slow-turnover airway epithelium
    J. K. Watson, S. Rulands, A. C. Wilkinson, A. Wuidart, M. Ousset, A. van Keymeulen, B. Gottgens, C. Blanpain, B. D. Simons and E. L. Rawlins
    Cell Reports 12, 90-101 (2015) | doi: 10.1016/j.celrep.2015.06.011

  27. Dynamic stem cell heterogeneity
    T. G. Krieger and B. D. Simons
    Development 142, 1396-1406 (2015) | doi:10.1242/dev.101063

  28. Deterministic progenitor behavior and unitary neuron production in the neocortex
    P. Gao, M. P. Postiglione, T. G. Krieger, L. Hernandez, C. Wang, Z. Han, C. Streicher, E. Papusheva, R. Insolera, K. Chugh, O. Kodish, K. Huang, B. D. Simons*, L. Luo*, S. Hippenmeyer*, and Song-Hai Shi*
    Cell 159, 775-788 (2014) | doi: 10.1016/j.cell.2014.10.027

  29. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
    F. Lescroart, S. Chabab, X. Lin, S. Rulands, C. Paulissen, A. Rodolosse, H. Auer, Y. Achouri, C. Dubois, A. Bondue, B. D. Simons, and C. Blanpain
    Nature Cell Biology 16, 829-840 (2014) | doi:10.1038/ncb3024

  30. Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
    L. Centanin, J. J. Ander, B. Hoeckendorf, K. Lust, T. Kellner, I. Kraemer, C. Urbany, E. Hasel, W. A. Harris, B. D. Simons, and J. Wittbrodt
    Development 141, 3472-3482 (2014) | doi 10.1242/dev.109892

  31. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo
    M. Amoyel, B. D. Simons and E. A. Bach
    EMBO J. 33, 2295-2313 (2014) | doi: 10.15252/embj.201387500
    Commentary: Stem cell competition: how speeding mutants beat the rest

  32. Quantification of the clonal evolution of human stem cells and crypts in normal, preneoplastic and neoplastic colon
    A.-M. Baker, B. Cereser, S. Melton, A. G. Fletcher, M. Rodriguez-Justo, P. J. Tadrous, G. Elia, S. A. C. McDonald, N. A. Wright, B. D. Simons*, M. Jansen*, T. A. Graham*
    Cell Reports 8, 940-947 (2014) | doi: 10.1016/j.celrep.2014.07.019
    Science Editor's Highlight
    Commentary: Stem cell competition: how speeding mutants beat the rest
    Commentary: Measuring stem cell dynamics in the human colon – where there's a wiggle, there's a way.

  33. Differentiation imbalance in single esophageal progenitor cells causes clonal immortalization and field change
    M. P. Alcolea, P. Greulich, A. Wabik, J. Frede, B. D. Simons and P. H. Jones
    Nature Cell Biology 16, 615-622 (2014) | doi: 10.1038/ncb2963

  34. Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states
    K. Hara, T. Nakagawa, H. Enomoto, M. Suzuki, M. Yamamoto, B. D. Simons* and S. Yoshida*
    Cell Stem Cell 14, 658-672 (2014) | doi: 10.1016/j.stem.2014.01.019
    Highlight: Sperm Spawned by Shifty, Shape-Shifting Stem Cells

  35. The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation
    M. Barbera, M. di Pietro, E. Walker, C. Brierley, S. Macrae, B. D. Simons, P. H. Jones, J. Stingl and R. C. Fitzgerald
    Gut 64, 11-19 (2015) | doi: 10.1136/gutjnl-2013-306171

  36. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
    L. Ritsma, S. I. J. Ellenbroek, A. Zomer, H. J. Snippert, F. J. de Sauvage, B. D. Simons, H. Clevers, and J. van Rheenen
    Nature 507, 362-365 (2014) | doi: 10.1038/nature12972
    Preview: Ballroom Dancing with Stem Cells: Placement and Displacement in the Intestinal Crypt

  37. Biased competition between Lgr5 intestinal stem cells by oncogenic K-ras induces clonal expansion
    H. J. Snippert, A. G. Schepers, J. H. van Es, B. D. Simons, and H. Clevers
    EMBO Reports 55, 62-69 (2014) | doi: 10.1002/embr.201337799

  38. Distinct fibroblast lineages determine dermal architecture in skin development and repair
    R. R. Driskell, B. M. Lichtenberger, E. Hoste,K. Kretzschmar, B. D. Simons, M. Charalambous, S. R. Ferron, Y. Herault, G. Pavlovic, A. C. Ferguson-Smith and F. M. Watt
    Nature 504, 277-281 (2013) | doi: 10.1038/nature12783

  39. Stem cell renewal theory turns 60
    B. D. Simons
    Nature Reviews: Molecular Cell Biology (journal club), 14, 754 (2013) | doi: 10.1038/nrm3706

  40. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
    V. H. Teixeira, P. Nadarajan, T. A. Graham, C. P. Pipinikas, J. M. Brown, M. Falzon, E. Nye, R. Poulsom, D. Lawrence, N. A. Wright, S. McDonald, A. Giangreco, B. D. Simons*, and S. M. Janes*
    eLife, 2013 Oct 22;2:e00966 | doi: 10.7554/eLife.00966 | PMCID: PMC3804062
    Commentary: Stem cells: What silent mutations say about the human airways

  41. Getting your gut into shape
    B. D. Simons
    Science (Perspective) 342, 203-204 (2013) | doi: 10.1126/science.1245288

  42. Unravelling stem cell dynamics by lineage tracing
    C. Blanpain and B. D. Simons
    Nature Reviews Molecular Cell Biology 14, 489-502 (2013) | doi: 10.1038/nrm3625

  43. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion
    D. G. Kent, J. Li, H. Tanna, J. Fink, K. Kirschner, D. C. Pask, Y. Silber, T. L. Hamilton, R. Sneade, B. D. Simons and A. R. Green
    PLoS Biology 11, e1001576 (2013) | doi: 10.1371/journal.pbio.1001576 | PMCID: PMC3672217

  44. Multipotent and unipotent progenitors contribute to prostate postnatal development
    M. Ousset, A. van Keymuelen, G. Bouvencourt, N. Sharma, Y. Achouri, B. D. Simons, and C. Blanpain
    Nature Cell Biology 14, 1131-8 (2012) | doi:10.1038/ncb2600

  45. How variable clones build and invariant retina
    J. He, G. Zhang, A. D. Almeida, M. Cayouette, B. D. Simons, and W. A. Harris
    Neuron 75, 786-798 (2012) | doi: 10.1016/j.neuron.2012.06.033 | PMCID: PMC3485567
    Preview: Deterministic or Stochastic Choices in Retinal Neuron Specification

  46. Distinct contribution of stem cells and progenitors to epidermal homeostasis and repair
    G. Mascre, B. Drogat, S. Dekoninck, K. K. Youseff, S. Brohee, P. Sotiropoulou, B. D. Simons*, and C. Blanpain*
    Nature, 489, 257-62 (2012) | doi: 10.1038/nature11393
    Research Highlight: Stem cells: Hierarchy in the population
    News and Views: Cell biology: Dormant and restless skin stem cells

  47. A single progenitor population switches behavior to maintain repair esophageal epithelium
    D. P. Doupe, M. P. Alcolea, A. Roshan, G. Zhang, A. M. Klein, B. D. Simons, and P. H. Jones
    Science 337, 1091-1093 (2012) | doi: 10.1126/science.1218835 | PMCID: PMC3527005
    Commentary: Science perspectives

  48. Defining the mode of tumour growth by clonal analysis
    G. Driessens, B. Beck, A. Caauwe, B. D. Simons*, and C. Blanpain*
    Nature 488, 527-530 (2012) | doi: 10.1038/nature11344
    Commentaries: Nature news | Nature, News and Views | Science Now | Cancer research UK |
    Press reports: ABC News | BBC News | Boston Globe | Dail Mail | eCancer | El Pais | Independent | LA Times | Medical Daily | NPR News | Telegraph | The Scientist
    Info: Stem cells and cancer

  49. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing stem cells
    J. de Navascues, C. Perdigoto, A. Bardin, A. Martinez-Arias, and B. D. Simons
    EMBO journal 31, 2473-85 (2012) | doi: 10.1038/emboj.2012.106 | PMCID: PMC3365418
    Commentary: Intestinal stem cells: no longer immortal but ever so clever...

  50. Patterning as a signature of human epidermal stem cell regulation
    A. M. Klein, D. P. Doupe, B. Nikolaidou-Neokosmidou, P. H. Jones and B. D. Simons
    J. R. Soc. Interface 8, 1815-1824 (2011) | doi: 10.1098/rsif.2011.0240 | PMCID: PMC3203489

  51. Stem cell self-renewal in intestinal crypt
    B. D. Simons and H. Clevers
    Experimental Cell Research 317, 2719-2724 (2011) | doi: 10.1016/j.yexcr.2011.07.010

  52. Universal patterns of stem cell fate in cycling tissues
    A. M. Klein and B. D. Simons
    Development 138, 3103-3111 (2011) | doi: 10.1242/dev.060103 |

  53. Strategies of stem cell self-renewal in adult tissues
    B. D. Simons and H. Clevers
    Cell 145, 851-862 (2011) | doi: 10.1016/j.cell.2011.05.033

  54. Reconstruction of rat retinal progenitor cell lineages reveals a surprising degree of stochasticity in cell fate decisions
    F. L. A. F. Gomes, G. Zhang, F. Carbonell, J. A. Correa, W. A. Harris, B. D. Simons, and M. Cayouette
    Development 138, 227-235 (2011) | doi: 10.1242/dev.059683 | PMCID: PMC3005599

  55. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    H. J. Snippert, L. G. van der Flier, T. Sato, J. H. van Es, M. van den Born, C. Kroon-Veenboer, N. Barker, A. M. Klein, J. van Rheenen, B. D. Simons, and H. Clevers
    Cell 143, 134-144 (2010) | doi: 10.1016/j.cell.2010.09.016
    Commentaries: Nature Reviews: Molecular Cell Biology | Developmental Cell | Nature News and Views

  56. Intestinal stem cell replacement follows a pattern of neutral drift
    C. Lopez-Garcia, A. M. Klein, B. D. Simons*, and D. J. Winton*
    Science 330, 822-825 (2010) | doi: 10.1126/science.1196236
    Commentary: Development

  57. Mouse germ line stem cells undergo rapid and stochastic turnover
    A. M. Klein, T. Nakagawa, R. Ichikawa, S. Yoshida, and B. D. Simons
    Cell Stem Cell 7, 214-224 (2010) | doi: 10.1016/j.stem.2010.05.017

  58. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia
    A. M. Klein, D. E. Brash, P. H. Jones, and B. D. Simons
    Proceedings of the National Academy of Sciences 107, 270-5 (2010) | doi: 10.1073/pnas.0909738107 | PMCID: PMC2806764

  59. The ordered architecture of ear epidermis is maintained by progenitor cells with random fate
    D. P. Doupe, A. M. Klein, B. D. Simons, and P. H. Jones
    Developmental Cell 18, 317 (2010) | doi: 10.1016/j.devcel.2009.12.016

  60. Epidermal homeostasis: do committed progenitors work while stem cells sleep?
    P. H. Jones and B. D. Simons
    Nature Reviews: Molecular Cell Biology 9 , 82-8 (2008) | doi: 10.1038/nrm2292

  61. Mechanism of murine epidermal maintenance: Cell division and the Voter Model
    A. M. Klein, D. P. Doupe, P. H. Jones, and B. D. Simons
    Phys. Rev. E. 77, 031907 (2008) | doi: 10.1103/PhysRevE.77.031907 | arxiv abstract

  62. Sic transit gloria: Farewell to the epidermal transit amplifying cell?
    P. H. Jones, B. D. Simons, and F. M. Watt
    Cell Stem Cell 1, 371 (2007) | doi: 10.1016/j.stem.2007.09.014

  63. Kinetics of cell division in epidermal maintenance
    A. M. Klein, D. P. Doupe, P. H. Jones, and B. D. Simons
    Phys. Rev. E. 76, 021910 (2007) | doi: 10.1103/PhysRevE.76.021910 arxiv abstract

  64. A single type of progenitor cell maintains the epidermis
    E. Clayton, D. P. Doupe, A. M. Klein, D. Winton, B. D. Simons, and P. H. Jones
    Nature 446, 185 (2007) | doi: 10.1038/nature05574 | pdf

  65. Vesicles and onion phases in dilute surfactant solutions
    B. D. Simons and M. E. Cates
    J. de Physique II (Paris) 2, 1439-1451 (1992) | doi: 10.1051/jp2:1992211

  66. Stability of dipolar fluid membranes
    B. D. Simons
    J. de Physique II (Paris) 2, 1141 (1992). | doi: 10.1051/jp2:1992192