Two new Post-doctoral Research Positions (NEW)



Experimental Post-Doctoral Research Associate Position in Cancer Cell Biology (Fixed Term)

Applications are invited for a postdoctoral position to explore experimentally the earliest steps of pre-neoplastic transformation in the epithelial tissues.

The position, which is supported by a Multidisciplinary Project Award from the CRUK, will be hosted in the Cambridge Stem Cell Institute (CSCI) and is associated with the research groups of Prof. Benjamin Simons (Physics/CSCI) and Dr. Bon-Kyoung Koo (Genetics/CSCI). Funds for this post are available until 31 January 2020 in the first instance.

This joint project aims at investigating the impact of tumorigenic mutations in the clone evolution from pre-neoplasia to invasive carcinoma, with an emphasis of the gastrointestinal tract. In order to advance our understanding in this field, we have developed novel variants of the Rosa-Confetti 4-colour reporter allele. These variants harbour different oncogenes, site-specific recombinase or Cas9 endonuclease coupled to a red fluorescent protein of the Rosa-Confetti lineage tracing system. Drawing upon developments in mathematical modelling, advanced imaging and image-analysis, we will define the clonal dynamics of tumorigenic mutation-containing clones as well as the response of surrounding normal clones in different adult tissues under different conditions: homeostasis, regeneration and/or inflammation. At the same time, we will perform Cas9-assisted in vivo genetic screening coupled with statistical analysis and imaging processing to determine genes associated with pre-neoplastic field cancerisation.

The successful applicant will lead the biological analysis of established lineage tracing models with confocal or multiphoton imaging analysis of near naïve epithelial tissues under the joint supervision of Dr Bon-Kyoung Koo and Prof Benjamin Simons. Quantitative biophysical analysis will be supported by the group of Prof Benjamin Simons (bds10 @cam.ac.uk).

Further information on the posts can be obtained by following this link.

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Theoretical Post-Doctoral Research Associate Position in Theoretical and Computational Biology (Fixed Term)

Applications are invited for a postdoctoral position to develop novel analytical, computational and statistical approaches to explore biological processes using single-cell genomics. The position, which is supported by a Wellcome Trust Strategic Award, will be associated with the research groups of Dr. John Marioni (CRUK Cambridge Institute/EMBL-EBI) and Prof. Benjamin Simons (Department of Physics/Wellcome Trust/CRUK Gurdon Institute) and can be based at the Wellcome Trust/CRUK Gurdon Institute or the CRUK CI with ready access to both Institutes.

Recent advances in single-cell genomics provide an exciting opportunity to gain mechanistic insight into the molecular processes underlying cell fate decision making in the developing embryo. Research groups in and around Cambridge are playing a leading role in the development and analysis of novel single-cell data. The successful applicant will be embedded within a major initiative, funded by a Wellcome Trust strategic award on “Tracing early mammalian lineage decisions by single cell genomics”, with access to single-cell transcriptional and epigenetic profiling data from the post-implantation developing mouse embryo. They will benefit from the rapidly expanding community of researchers in Cambridge interested in developing the interface between Physical and Biological/Biomedical Sciences. The successful applicant will contribute to the development of novel statistical, computational and analytical approaches to study mechanistic processes in the regulation of lineage priming and cell fate decisions. The groups of Prof. Benjamin Simons and Dr. John Marioni are interested in using single-cell sequencing data to understand molecular mechanistic processes occurring in developing and adult tissues, as well as processes leading to dysregulation in tumour initiation and progression. A hallmark of these groups is the existence of close and reactive collaborations with experimental cell biologists, both within and outside Cambridge.

Successful candidates will hold (or be about to complete) a PhD/DPhil in an area of Theoretical Physics, Biological Physics, Mathematics, Bioinformatics, Computational Biology or a closely related field.

As well as those with training in theoretical biophysics, the group is very much open to the recruitment of post-doctoral researchers with a strong track-record of research in the field of statistical physics, condensed matter theory or applied mathematics, including those who have an interest in, but no experience of, the study of biological systems. For these candidates, a secure knowledge of methods of non-equilibrium physics and/or population dynamics is essential, and an aptitude for computer programming is useful.

The length of contract will be two years with the potential for an extension to a third year of support. Depending on the background and interests of the successful applicant, he/she will be based at the Wellcome Trust/CRUK Gurdon Institute or the CRUK Cambridge Institute.

Please submit applications in the following format: a CV, including full details of previous training and research experience to date; a publication record if available; the names and contact details of two referees; a summary of prior research accomplishments, and a statement of future research interests. Further information on the post can be obtained by referring to the group website or contacting Benjamin Simons (bds10 @cam.ac.uk) or John Marioni (john.marioni @cruk.cam.ac.uk). The closing date for applications is 5th March 2017.

Further information on the posts can be obtained by following this link.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.




Graduate studies: Biology (Theory and Experiment)



During the current academic year, the group may be seeking to appoint at least one graduate student in the area of biological physics to start in October 2017.

Alongside projects involving the development of theoretical approaches to biology, we especially welcome applications from students interested in undertaking joint experimental and theoretical work with partner laboratories in Cambridge. Current research interests include the exploitation of genetic lineage tracing assays to study patterns of stem and progenitor cell fate in adult and developing tissues. The group is also interested in the study of pathways leading to the dysregulation of stem cells in disease models.


Futher projects involving the synthesis of transcriptome and epigenome data to explore dynamical heterogeneity of gene expression in embryonic stem cells are planned. We are also interested in using deep sequencing data to explore the evolutionary dynamics of viruses.


Further information on available projects will be made available early in the new year. EU and Non-EU applicants should note the funding requirements of the University and they should ensure that their application meets the deadlines imposed by appropriate funding schemes. For further details of the arrangements at the Cavendish, we refer to the following link.





Graduate studies: Physics



We regret that the group will not be recruiting graduate students in theoretical quantum condensed matter physics this year.