Curriculum Vitae
Matthew Segall

Date of Birth:20th June 1972 Nationality:American (Permanent U.K. resident)
Address:Cavendish Laboratory (TCM)
Madingley Road
Cambridge
CB3 0HE
Telephone:(01223) 337359
E-mail:mds21@phy.cam.ac.uk
Education
1997PhD in Physics Completed
Clare Hall and Cavendish Laboratory, University of Cambridge

1994MSc in Comutation awarded with Distinction
1993BA Honours in Physics, Class 2(i) awarded
Lincoln College, University of Oxford

19903 GCE `A' Levels (results;3xA), 2 GCE `S' Levels (results; 2x1)
19885 GCSEs (results;5xA), 2 GCE `AO' Levels (results; A,C)
19874 GCE `O' Levels (results;2xA,2xB)
St. Albans School, St. Albans, Hertfordshire
Employment
1998-Reseach Fellow, Darwin College, Cambridge.
1997-Research Associate, TCM Group, Cavendish Laboratory, University of Cambridge.
1996-1997Computing Officer, TCM Group, Cavendish Laboratory, University of Cambridge.
1996-1998World-wide Web administrator for Corpus Christi College.
1994-Supervisor in Quantitative Biology, Pembroke, Corpu Christi and St Catherine's Colleges.
1994Freelance technical writer for Acorn User, Europress Ltd.
1987-1993Part-time and vacation work at Beebug Ltd., St. Albans, a computer retailer specialising in Acorn computers. Responsibilities; sales, public relations and technical advice.
Computing Experience
Languages:CC++
FORTRAN77Fortran90
HTMLPascal
BASICOberon
Operating Systems:UnixWindows 95
Windows NTMS DOS
RISC OS
Miscellaneous:Member of informal steering group for Cambridge University High Performance Computing Facility.
Member of TCM Linux PC administration group (1995-1998).
Webmaster for TCM Group, Cavendish Laboratory (1994-)
Member of Clare Hall Computing Sub-committee (1994-1997).
Member of Darwin College Computing Committee (1998-).
Research Interests
The research which formed the dissertation submitted towards my MSc in Computation involved the development of software for the analysis and visualisation of the human cornea in three-dimensions using data derived from ultrasound scanning {\it in vivo}. The ability to visualise this information will enable the refinement of surgical techniques for sculpting the cornea in order to remove defects or treat conditions such as short-sightedness. This work was undertaken in collaboration with the Department of Opthalmology at the Cornell University Medical College, New York.
The work which formed my PhD dissertation and comprises the primary focus of my current research, concerns the application of first principles quantum mechanical modeling to molecular biology. These techniques are more accurate than conventional methods and offer the capability to model significantly larger systems, allowing the mechanisms of reactions to be simulated and their outcomes predicted. The current target of this study are the cytochromes P450, a ubiquitous superfamily of enzymes of great importance to the pharmaceutical industry due to their participation in the metabolism of many drug compounds. This work was conducted in collaboration with Professor G.T. Tucker and Dr S.W. Ellis of the University of Sheffield and Dr R.N. Boyes of ML Laboratories plc, after consultation with Professor D.S. Davies of the Royal Postgraduate Medical School, London.

I have continued my research into Cytochrome P45 and this is now being funded by Glaxo Wellcome Reasearch and Development.

Contributed Presentations
The Application of Ab-initio Quantum Mechanical Calculations to the Structure of Acetylcholine. M.D. Segall, M.C. Payne, R.N. Boyes. Poster presented at UKaps Annual Conference, Nottingham, April 1995.
Population Analysis in Plane Wave Electronic Structure Calculations. M.D. Segall, C.J. Pickard, R. Shah, M.C. Payne. Talk presented at CMMP '96, York, December 1996.
Ab Initio Electronic Structure Calculations of Cytochrome P450 - Ligand Interactions. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Talk presented at APS March Meeting, Kansas City, March 1997.
Drug Metabolism from First Principles. M.D. Segall, M.C. Payne. Poster and talk presented at HPCN '97, Vienna.
Ab Initio Molecular Modeling in the Study of Drug Metabolism. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Presented at `Drug Metabolism: Towards the Next Millennium', Kings College London, August 1997.
Ab Initio Molecular Modeling of Intermediate States in the Cytochrome P450 Catalytic Cycle. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Presented at APS March Meeting, Los Angeles, March 1998.
Ab Initio Study of the Oxygen-bound and Active Complexes of Cytochrome P450}. M.D. Segall, M. C. Payne, S.W. Ellis, G.T. Tucker, P.J. Eddershaw. Presented at APS Centenial Meeting, Atlanta, March 1999.
Invited Presentations
Ab Initio Modeling of Cytochrome P450. 1999 Glaxo Wellcome P450 Modeling Symposium. Research Triangle Park, April 1999.
The Role of ab Initio Quantum Mechanical Simulations in Biology: Application to Cytochrome P450. M.D. Segall, M. C. Payne, P.J. Eddershaw. Presented at ASCEPT/BPS Join Meeting, Melbourne, April 2000.
Publications
Computer Aided High-frequency Ultrasound Simultaneous Three-dimensional Corneal Pachymetric and Keratometric Topography. M.D. Segall, D.Z. Reinstein, N.F. Johnson, I.M. Aslanides, R.H. Sliverman, D.J. Coleman. Investigative Opthalmology & Visual Science, 1995, 36, 4, p.S379.
Population Analysis in Plane Wave Electronic Structure Calculations. M.D. Segall, C.J. Pickard, R. Shah, M.C. Payne. Mol. Phys. 1996, 89, 2, p. 571
A First Principles Study of a Tilt Grain Boundary in Rutile.I. Dawson, P.D. Bristowe, M-H. Lee, M.C. Payne, M.D. Segall, J.A. White. Phys. Rev. B, 1996, 54, 19, p. 13727
Simultaneous 3-D Pachymetry and Keratometry of the Full Cornea Using a New High-frequency Ultrasound Multi-directional Scanning System.D.Z. Reinstein, R.H. Silverman, T. Raevsky, M.D. Segall, N.F. Johnson, D.J. Coleman. Investigative Opthalmology and Visual Science, 1996, 37, 3, p.2571.
Population Analysis of Plane Wave Electronic Structure Calculations of Bulk Materials. M.D. Segall, R. Shah, C.J. Pickard, M.C. Payne, I. Dawson. Phys. Rev. B, 1996, 54, 23, p. 16317
3-D Thickness and Shape of the Cornea by Very High-Frequency Ultrasound Meridional Scanning. D.Z. Reinstein, R.H. Silverman, T. Raevsky, M.D. Segall, N.F. Johnson, D.J. Coleman. J. Ultrasound Med., 1997, 16(3);S14.
Stromal and epithelial surface smoothness in normal and post-PRK corneas in vivo by very high-frequency ultrasound. D.Z. Reinstein, A. Cusumano, R.H. Silverman, M.J. Rondeau, M.D. Segall, N.F. Johnson, D.J. Coleman. Investigative Ophthalmology and Visual Science, 1997, 38, p. 2486
An ab Initio Approach to the Understanding of Cytochrome P450 - Ligand Interactions. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Xenobiotica 28 pp. 15-20.
An ab Initio Study of the Conformational Energy Map of Acetylcholine. M.D. Segall, M.C. Payne, R.N. Boyes. Molecular Physics 93 pp. 365-370 (1998).
Ab Initio Molecular Modeling in the Study of Drug Metabolism. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. European J. Drug Metab. & Pharmacokin. 22 pp. 283-289 (1997).
First Principles Calculation of the Activity of Cytochrome P450. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Phys. Rev. E 57 p. 4618 (1998).
Evidence for Stabilisation of Low Spin State of Cytochrome P450 due to Shortening of the Proximal Haem Bond M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, R.N. Boyes. Chem. Res. Toxicol. 11 pp. 962-966 (1998).
First Principles Investigation of Singly-reduced Cytochrome P450. M.D. Segall, M.C. Payne, S.W. Ellis, G.T. Tucker, P.J. Eddershaw. Xenobiotica 29 pp. 561-571
Computer Aided Analysis and Visualisation of Very High-frequency Ultrasound Scans of the Human Cornea. M.D. Segall, D.Z. Reinstein, N.F. Johnson. IEEE Computer Graphics and Applications 19(4) pp. 74-82
Activities and Interests
School:Completed Duke of Edinburgh Silver Award.

University:Vice-president of Clare Hall Graduate Student Body.
Committee member, Oxford University Microcomputer Society.
Rowed in Lincoln College novice `A' crew.
Member of Lincoln College pool and tennis teams.
Member of Cambridge Dancers Club.
Co-editor of Lincoln College satirical broad-sheet `Imperative'.

Swimming:Member of City of St. Albans A.S.C.
Staff member of Abbey Bathers A.S.C.

Matthew Segall (mds21@phy.cam.ac.uk)
Last modified: Mon Jun 26 16:30:00 2000