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Theory of Living Matter Group

 

Organizers (in alphabetial order)

Shlomit Edri

PhD student

Department of Genetics

Email:

Research Interests

  • Developmental biology and cell fate assignments
  • Dynamic of the neural-mesodermal progenitors of mammalian embryos
  • Computational modelling

Shlomit joined Alfonso Martinez-Arias' lab in the department of Genetics as a PhD student in 2015. In her PhD she is combining experimental biology work on mouse embryonic stem cells and her engineering background to better understand how chemical signalling and self-cell organization influence the balance between self-renewing stem cells and their decision to differentiate.


Adrien Hallou

Postdoctoral Research Associate

Department of Physics, Gurdon Institute and Stem Cell Institute

Email:

Research Interests

  • Stem cell dynamics in epithelial tissues
  • Cell fate decisions
  • Embryonic pattern formation
  • Mechanotransduction
  • Collective cell migration in development and cancer

Initially trained as a physicist and a chemist, Adrien developed his interest for quantitative approaches of biological systems during his MPhil and PhD in Biophysics at the University of Cambridge. He is now a postdoctoral research fellow in the group of Prof. Ben Simons, and combines theory, computer simulations and wet lab experiments to understand the role of cellular heterogeneity in cell fate decision, pattern formation and epithelial tissue function during homeostasis, regeneration and tumorogenesis.


Édouard Hannezo

Postdoctoral Research Associate

Department of Physics and Gurdon Institute

Email:

Research Interests

  • Epithelial mechanics and morphological transitions in three dimensions
  • Stem cell kinetics during development
  • Collective cell migration
  • Cortical instabilities in pattern formation

Edouard is trained as a theoretical biophysicist, and uses methods from soft matter, hydrodynamics and mechanics to study the morphogenesis of epithelial tissues, as well as cancer initiation, in collaboration with experimental biologists. He also likes to do a bit of experimental work from time to time!


David Jörg

Postdoctoral Research Associate

Department of Physics and Gurdon Institute

Personal website
Email:
Publications: http://www.davidjorg.com/publications.php

Research Interests

  • Stem cell dynamics in tissue development, maintenance, and repair
  • Biochemical feedback systems and genetic oscillations
  • Embryonic pattern formation
  • Synchronisation in biology and engineering

Having a background in quantum many-particle theory, David became interested in the theoretical understanding of collective phenomena in living systems. His current main focus is on how the pool of stem cells that maintains adult tissue is regulated through biochemical signaling and how it recovers after injury. In addition, he works on embryonic pattern formation such as the segmentation of the vertebrate body axis and the development of the fly visual system. David is also involved in transferring the insights obtained in living systems to engineering concepts for technical applications.


Céline Labouesse

Postdoctoral Research Associate

Stem Cell Institute

Email:

Research Interests

  • Stem cell fate decisions
  • Mechanobiology, mechanotransduction
  • Cytoskeleton and cell mechanical properties
  • Nuclear mechanics

Céline has background in physics and cell biophysics. After working on mechanical properties of cytoskeletal structures during her PhD in EPFL, Switzerland, she joined the group of Kevin Chalut at the Stem Cell Institute in 2015 to study the mechanical control of embryonic stem cell fate. In particular, she looks at how external forces from the micro-environment are transduced to the cell and the nucleus and ultimately impact cell fate decisions.


Imen Lassadi

Postdoctoral Research Associate

Department of Biochemistry

Email:

Research Interests

  • Chromatin Biology and Genome architecture
  • DNA maintenance and stability
  • Imaging and Image analysis

Dr Imen Lassadi obtained her PhD from Paul Sabatier University in Toulouse, France. During her PhD, she was involved in developing a multi-color tagging technique as well as a geometry-based software to study the organization of chromosomes in S. cerevisiae. After a post-doctoral stay in Pasteur Institute-Paris, where she worked on the impact of genome architecture and chromatin compaction in DNA damage repair in S. cerevisiae. Imen joined Dr Ross Waller' lab in the Department of Biochemistry as a Research Associate in 2016. She is studying the genome organization of Dinoflagellata which provide a model for a histone-independent mechanism of nuclear genome maintenance and function.


Xiaoyan Ma

Postdoctoral Research Associate

Department of Biochemistry

Email:

Research Interests

  • Chromosome organisation
  • Transcription factor binding dynamics and spatial co-localisation
  • Computational biology
  • Stem cell differentiation

Xiaoyan has a background in biochemistry and computational biology. She did her PhD in Genetics investigating transcription factor binding dynamics and 3D co-localisation in mammalian genome, using a combination of biophysical modelling and chromatin contact map analysis. Xiaoyan joined Prof. E. D. Laue's group in Oct 2017 to further her research on chromosome organisation in single nucleus.


Ben Steventon

Group Leader

Department of Genetics

Personal website
Email:
Publications: https://steventonlab.wordpress.com/publications/

Research Interests

  • Comparative developmental biology
  • Cell lineage analysis of neuromesodermal progenitors during vertebrate axis elongation
  • The role of gene expression heterogeneity in the maintenance of multipotency

Ben is an experimental biologist interested in the molecular and cellular processes that drive the elongation of the vertebrate body axis. His current work focusses on assessing the role of gene expression heterogeneity in the maintenance of a bipotent stem cell population termed 'neuromesodermal progenitors' that generate both neural and mesodermal progenitors as the body axis extends. He is particularly interested in how divergent cellular behaviours are generated by seemingly conserved signal and gene regulatory networks across a range of vertebrate species.


Vikas Trivedi

Postdoctoral Fellow

Department of Genetics

Email:

Research Interests

  • Developmental biology
  • Computational modelling
  • Modern microscopy

Vikas joined the Department of Genetics as a Herchel Smith Fellow in 2016, coming from California Institute of Technology (Caltech, USA) where he did a PhD in Bioengineering. An engineer by training and with expertise in developmental biology, computational modeling and modern microscopy, he is interested in understanding the interplay of mechanical forces and chemical signaling that drive the beautiful self-assembly of cells to shape a developing embryo. He loves teaching and enjoys discussions across disciplines.