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Theory of Living Matter Group


5th General Meeting

General information

This meeting will be jointly organised with NanoDTC and it will be focussed on the biophysics of subcellular structures and of cells contributing to morphogenesis. On this special occasion we have two external speakers who are renowned experts in studying the dynamics of the cytoskeleton and of developing tissues: Prof Yohanns Bellaïche and Prof Ewa Paluch.

After the talk there will be a drinks reception with snacks and plenty of time for informal discussions.

Registration closed.

Thursday, 4th June December 2015, 6pm

Main lecture theatre, Sainsbury Laboratory
Bateman Street, Cambridge CB2 1NN

Directions: The Sainsbury Laboratory Cambridge University is located in Cambridge University Botanic Garden and can be accessed via Bateman Street. Note that the entrance to the Sainsbury Laboratory is rather hidden in the backyard of an arts school. There will be signs and people waiting to guide the way.


“Cell division and epithelial tissue morphogenesis”

Yohanns Bellaïche, Institut Curie, CNRS, Paris

Questions related to embryo shape or morphogenesis have haunted developmental biologists for decades. Recent advances in imaging, cell biology, signal transduction and biophysics have framed the study of tissue morphogenesis in terms of collective cell dynamics and the interplay between biochemical and mechanical processes. Recent findings have confirmed that proliferative epithelial tissues reshape via morphogenetic processes such as cell shape change and cell rearrangements. Yet cell division remodels adherent junctions and modulates both tissue mechanics and tissue dynamics. Therefore its role and interplay with the other morphogenetic processes need to be understood to decipher the mechanisms of tissue morphogenesis. Moreover, given the large size of some proliferative tissues, challenging questions can be addressed: How do local and long-range mechanical effects contribute to tissue dynamics? How do the combinations of several signaling pathways or gene expression patterns specify distinct local cell dynamics leading to the emergence of several morphogenetic movements within a given tissue? During my talk I will describe some of our latest works that aim to understand the mechanisms of mitotic.

“Actin Cortex mechanics in Cell Morphogenesis”

Ewa Paluch, University College London

(No abstract available.)